Patients with persistent MOG antibodies may benefit from addition of immunosuppressant agents, which may decrease the number of attacks.Ĭopyright © 2016 by the American Academy of Pediatrics. It was thought to be associated with steroid-dependent course, and azathioprine and intravenous human immunoglobulin treatment were added. The positivity of this antibody remained. We were able to search MOG antibody at the ninth attack. During follow-up, she experienced repeated episodes after steroid therapy termination. ADEM was diagnosed and treated with steroid. Periventricular white matter lesions were seen on cranial magnetic resonance imaging studies. A 6-year-old girl was consulted with encephalopathy, gait disturbance, and oculomotor nerve palsy. Other studies have shown contradictory associations between sex and MOG ON. Children with MOG ADEM had up to an 80 chance of developing MOG ON in adolescence or adulthood in one study. In contrast to NMOSD which is more frequently seen in African and Asian ancestry. Here we report a unique case with persistent MOG antibodies presented with multiphasic ADEM-like attacks. MOG ON can be seen in any age, any ethnicity, and in either gender. However, persistent MOG antibodies are considered as a predicting factor for multiple sclerosis, optic neuritis relapses, and incomplete recovery of ADEM. MOG antibodies have been shown to be positive in high titers during the first episode of ADEM with rapidly decreasing to undetectable limits after recovery. It may give prognostic information regarding monophasic or recurrent course of the disease. Neurological update: MOG antibody disease.Myelin oligodendrocyte glycoprotein (MOG) is a candidate target antigen in demyelinating central nervous system diseases, including acute disseminated encephalomyelitis (ADEM), neuromyelitis optica, and multiple sclerosis.
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